Cycloalkyl ether compounds and their use as BACE inhibitors

US9000185B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• Sofia Karlstrom · Macclesfield, GB
• Peter Soderman · Grafton, GB
• Britt-Marie Swahn · Grafton, GB
• Laszlo Rakos · Malung, SE
• Liselotte Ohberg · Malung, SE

Key dates

• Filing date: Jun 13, 2013
• Grant date: Apr 7, 2015
• Expiry date: Jun 13, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Cycloalkyl ether compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration and pharmaceutical compositions containing such compounds.