Patent · US Active

Methods and compositions for the inhibition of transplant rejection

US9005616B2 · kind B2 · utility

6Cited by
84References
40Claims
0Family size

Assignee

Inventors

Key dates

Filing dateAug 31, 2010
Grant dateApr 14, 2015
Priority date—
Expiry dateAug 31, 2030

Classification

  • Technology area (CPC G)Physics
  • CPC primaryG01N2800/52
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Methods for modulating immune responses in a subject are provided. A preferred embodiment provides methods and compositions for reducing or inhibiting transplant rejection in a subject, preferably a human subject. Transplant rejection can be inhibited or reduced in a subject by administering an effective amount of B7-H4 polypeptide, fragments or fusions thereof to inhibit or reduce the biological activity of an immune cell or to reduce the amounts of proinflammatory molecules at a site of transplant. Th1, Th17 and Th22 cells are exemplary T cells that can be targeted for inhibition by B7-H4 polypeptides, fusion proteins or fragments thereof to inhibit or reduce inflammation.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.