Patent · US Active

Antikine antibodies that bind to multiple CC chemokines

US9005617B2 · kind B2 · utility

0Cited by

4References

19Claims

0Family size

Assignee

REGENERON PHARMACEUTICALS, INC. · US

Inventors

Dan Scott Allison · Port Orchard, US
Carol Raport · Bothell, US

Key dates

Filing date	Oct 22, 2012
Grant date	Apr 14, 2015
Priority date	—
Expiry date	Oct 28, 2032

Classification

Technology area (CPC G)Physics
CPC primaryG01N2333/523
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

An antikine antibody binds to two, three, four, five or more CC chemokines, such as RANTES/CCL5, MIP-1α/CCL3, MIP-1β/CCL4, or MCP-1/CCL2. Methods for affinity maturation and humanization of antikine antibodies as well as the production of hybridoma cell lines producing antikine antibodies by sequential immunization are also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.