Binding molecules capable of neutralizing rabies virus and uses thereof

US9005624B2 · kind B2 · utility

Assignee

• Crucell Holland B.V. · NL

Inventors

• Alexander Berthold Hendrik Bakker · Utrecht, NL
• Willem Egbert Marissen · Leiden, NL
• Robert A. Kramer · Crown Point, US
• Cornelis Adriaan De Kruif · De Bilt, NL

Key dates

• Filing date: Apr 8, 2010
• Grant date: Apr 14, 2015
• Expiry date: Jun 13, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/20122
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. Further provided are nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from rabies virus. In certain embodiments, they can be used in the post-exposure prophylaxis of rabies.