Repeat protein from collection of repeat proteins comprising repeat modules

US9006389B2 · kind B2 · utility

Assignee

• Universitat Zurich · CH

Inventors

• Michael Tobias Stumpp · Geroldswil, CH
• Patrik Forrer · Schlieren, CH
• Hans Kaspar Binz · Beaumont, FR
• Andreas Plückthun · Zürich, CH

Key dates

• Filing date: Dec 19, 2011
• Grant date: Apr 14, 2015
• Expiry date: Dec 19, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/1093
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A repeat protein from a collection of repeat proteins, wherein each repeat protein of said collection comprises a repeat domain, which comprises a set of consecutive repeat modules, wherein the repeat modules have the same fold and stack tightly to create a superhelical structure having a joint hydrophobic core, wherein each of the repeat modules is derived from one or more repeat units and wherein the repeat units comprise framework residues, which contribute to the folding topology of the repeat unit or contribute to an interaction with a neighboring repeat unit, and target interaction residues, which contribute to an interaction with a target substance, wherein the repeat proteins of the collection differ from other repeat proteins in the collection in at least one amino acid position of the repeat modules is described as are related pharmaceuticals and nucleic acid molecules.