Conjugate addition reactions using bifunctional cinchona-alkaloid-based catalysts
US9006441B2 · kind B2 · utility
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Key dates
| Filing date | May 9, 2014 |
| Grant date | Apr 14, 2015 |
| Priority date | — |
| Expiry date | May 9, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/327
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
One aspect of the present invention relates to quinine-based and quinidine-based catalysts. Another aspect of the present invention relates to a method of preparing a chiral, non-racemic compound from a prochiral electron-deficient alkene, comprising the step of: reacting a prochiral electron-deficient alkene with a nucleophile in the presence of a catalyst; thereby producing a chiral, non-racemic compound; wherein said catalyst is a derivatized quinine or quinidine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.