Process for preparing aminocyclohexyl ether compounds

US9006460B2 · kind B2 · utility

Assignee

• Cardiome International AG · CH

Inventors

• John Limanto · Jersey City, US
• Gregory L. Beutner · Green Brook, US
• Jingjun Yin · Haddonfield, US
• Artis Klapars · Scotch Plains, US
• Eric R. Ashley · Fanwood, US
• Hallena Strotman · Somerville, US
• Matthew Truppo · Tinton Falls, US
• Cheol K. Chung · South San Francisco, US
• Gregory Hughes · Scotch Plains, US
• Zhijian Liu · Lo Wu, CN
• Brendan T. Grau · Warrington, US
• Jacob Janey · New York, US

Key dates

• Filing date: Aug 8, 2011
• Grant date: Apr 14, 2015
• Expiry date: Aug 8, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P17/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for preparing aminocyclohexyl ether compounds of Formula I: or the pharmaceutically acceptable salts and esters thereof. In particular, the instant invention is directed towards a process for preparing (1R,2R)-2-[(3R)-Hydroxypyrrolidinyl]-1-(3,4-dimethoxyphenethoxy)-cyclohexane as well as various intermediates.