Fibronectin targeting contrast agent

US9011816B2 · kind B2 · utility

Assignee

• CASE WESTERN RESERVE UNIVERSITY · US

Inventors

• Zheng-Rong Lu · 红钢城街道, CN
• Xueming Wu · 安丰镇, CN

Key dates

• Filing date: Mar 25, 2011
• Grant date: Apr 21, 2015
• Expiry date: Jun 14, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K51/088
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Example systems and methods enhance contrast in MRI images. To facilitate imaging of atherosclerotic plaques, arterial and venous, cardiac, and even tumor tissues and fibrosis, a fibrin-fibronectin complex or disease-related fibronectin specific MRI contrast agent (CLPD) has a specific binding affinity for fibronectin.