Activated mesenchymal stem cells for wound healing and impaired tissue regeneration
US9011840B2 · kind B2 · utility
3Cited by
5References
11Claims
0Family size
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Key dates
| Filing date | May 30, 2012 |
| Grant date | Apr 21, 2015 |
| Priority date | — |
| Expiry date | May 30, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/24
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Inflammatory cytokines e.g. IFN-γ, serve as initiating stimuli for mesenchymal stem cell (MSC) immunosuppresive activity in vivo. Other inflammatory cytokines, such as TNF alpha, the molecule hemoxygenase I, and TLR ligation of MSC, may also provide such a response. Activated MSC's promote tissue regeneration in conditions such as aging, where regeneration is impaired. Wound healing in aged mammals was enhanced by restoring tensile strength to the levels of younger mammals. Activated MSCs were useful in treating wounds in diabetic primates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.