Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates

US9011864B2 · kind B2 · utility

Assignees

• Biotest AG · DE
• IMMUNOGEN, INC. · US

Inventors

• Gregor Schulz · Umkirch, DE
• Christoph Bruecher · Eschborn, DE
• Frank Osterroth · Dietzenbach, DE
• Steffen Zeng · Munster, DE
• Christoph Uherek · Seligenstadt, DE
• Silke Aigner · Bischofswerda, DE
• Benjamin Daelken · Frankfurt am Main, DE
• Markus Ruehle · Wiesbaden, DE
• Elmar Kraus · Bad Vilbel, DE

Key dates

• Filing date: Dec 23, 2008
• Grant date: Apr 21, 2015
• Expiry date: Dec 23, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/34
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are methods, compositions and kits for improving targeting, in particular tumor targeting, of immunoconjugates. The method and composition relies on the sequestration of non-target cells that also express the antigen the immunoconjugate targets. Sequestration of those non-target cells in a variety of ways is disclosed. The methods, compositions and kits allow appropriate sequestration of non-target cells while maintaining a high degree of effectiveness of the immunoconjugates against target cells.