Cationic lipids for therapeutic agent delivery formulations

US9011903B2 · kind B2 · utility

Assignee

• NITTO DENKO CORPORATION · JP

Inventors

• Yoshiro Niitsu · Sapporo, JP
• Victor Knopov · Oceanside, US
• Joseph E. Payne · San Diego, US
• Zheng Hou · San Diego, US
• John A. Gaudette · Poway, US
• Violetta Akopian · Oceanside, US
• Richard P. Witte · San Diego, US
• Mohammad Ahmadian · Carlsbad, US
• Loren A. Perelman · San Diego, US
• Yasunobu Tanaka · Osaka, JP
• Priya Karmali · San Diego, US
• Sridhar C. Nagarajan · San Diego, US

Key dates

• Filing date: Jun 8, 2012
• Grant date: Apr 21, 2015
• Expiry date: Jun 8, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/113
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Here described are compounds of formula I:wherein R1 and R2 is independently selected from a group consisting of C10 to C18 alkyl, C12 to C18 alkenyl, and oleyl group; wherein R3 and R4 are independently selected from a group consisting of C1 to C6 alkyl, and C2 to C6 alkanol; wherein X is selected from a group consisting of —CH2—, —S—, and —O— or absent; wherein Y is selected from —(CH2)n, —S(CH2)n, —O(CH2)n—, thiophene, —SO2(CH2)n—, and ester, wherein n=1-4; wherein a=1-4; wherein b=1-4; wherein c=1-4; and wherein Z is a counterion; as well as compositions and pharmaceutical formulations including compounds of formula I which are useful for the delivery of therapeutic agents; and methods of using these compositions and formulations.