Patent · US Active

Compositions for targeted delivery of siRNA

US9011919B2 · kind B2 · utility

3Cited by

0References

22Claims

0Family size

Assignee

Arrowhead Madison, Inc. · US

Inventors

David B. Rozema · Madison, US
David L. Lewis · Madison, US
Darren H. Wakefield · Fitchburg, US
Torsten Hoffmann · Weil am Rhein, DE
Eric A. Kitas · Aesch, CH
Peter Mohr · Basel, CH
Philipp Hadwiger · Kulmbach, DE
Wilma Thuer · Kulmbach, DE
Linda Valis · Bamberg, DE

Key dates

Filing date	Sep 14, 2012
Grant date	Apr 21, 2015
Priority date	—
Expiry date	Apr 18, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2310/3515
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.