CD127 expression inversely correlates with FoxP3 and suppressive function of CD4+ Tregs
US9012134B2 · kind B2 · utility
2Cited by
3References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 31, 2007 |
| Grant date | Apr 21, 2015 |
| Priority date | — |
| Expiry date | Feb 20, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/7155
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides methods of isolating CD127lo/− immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding the isolated cells, pharmaceutical compositions of such cells, and methods of their use in the treatment of autoimmune and other immune system mediated disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.