FGF receptor-activating N-acyl octasaccharides, preparation thereof, and therapeutic use thereof

US9012413B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Pierre Alexandre DRIGUEZ · Paris, FR
• Philippe Duchaussoy · Toulouse, FR
• Pierre Fons · Paris, FR
• Corentin Herbert · Paris, FR
• Gilbert Lassalle · Paris, FR

Key dates

• Filing date: Feb 9, 2012
• Grant date: Apr 21, 2015
• Expiry date: Aug 26, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08B37/0075
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to FGF receptor-activating N-acyl octasaccharides having Formula (I), wherein: R1 is an O-alkyl group optionally replaced by one or more aryl or cycloalkyl groups, R2 is an OSO3− or hydroxyl group, R3 is an alkyl, cycloalkyl, or alkyl-cycloalkyl group, R4 is a disaccharide having Formula (II), R6 is a disaccharide having Formula (III), and R8 is a disaccharide having Formula (IV), where R5, R7, and R9 are OSO3− or hydroxyl groups. The invention further relates to the preparation of said octasaccharides and to the therapeutic use thereof.