Crystalline naloxol-peg conjugate

US9012469B2 · kind B2 · utility

Assignees

• ASTRAZENECA AB · SE
• Nektar Therapeutics · US

Inventors

• Bengt Leonard Aslund · Gately Drive, SE
• Carl-Johan Aurell · Timrå, SE
• Martin Bohlin · Stockholm, SE
• Eric Thomas Healy · Waltham, US
• David Richard Jensen · Waltham, US
• David Jonaitis · Lafayette, US
• Stephan D. Parent · West Lafayette, US
• Tesfai Sebhatu · Malung, SE
• Bo Ingvar Ymén · Gately Drive, SE

Key dates

• Filing date: Sep 29, 2011
• Grant date: Apr 21, 2015
• Expiry date: Apr 2, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Naloxol-polyethlyene glycol conjugates of the formula: are provided in oxalate or phosphate salt forms including crystalline forms. Methods of preparing the salt forms and pharmaceutical compositions comprising the salt forms are also provided.