Therapeutic 5,6,5-tricyclic analogs
US9012470B2 · kind B2 · utility
0Cited by
3References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 11, 2011 |
| Grant date | Apr 21, 2015 |
| Priority date | — |
| Expiry date | Aug 22, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a novel chemical series of formula I, as well as methods of use thereof for binding to the benzodiazepine site of the GABAA receptor and negatively modulating the α5 subtype of GABAA, and use of the compound of formula I in the manufacture of a medicament for the treatment of GABAA receptor associated disorders. The invention further provides a method of modulation of one or more GABAA subtypes in an animal comprising administering to the animal an effective amount of a compound of formula (I).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.