Glucose metabolism modulating compounds

US9012471B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Paul William Richard Harris · Richmond, US
• Antonella Maffei · New York, US
• Yuli Xie · Shanghai, CN
• Donald W. Landry · New York, US

Key dates

• Filing date: Apr 10, 2009
• Grant date: Apr 21, 2015
• Expiry date: Apr 18, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides, inter alia, dihydropyridone compounds and compositions, including analogs of a vesicular monoamine transporter type 2 (VMAT2) antagonist. The present invention also provides methods of using such compounds/analogs for modulating glucose levels, and/or preventing, treating, or ameliorating the effects of diabetes and hyper-glycemia.