Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament

US9012489B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Riccardo Giovannini · Verona, IT
• Barbara Bertani · Castiglione delle Stiviere, IT
• Marco Ferrara · San Donato Milanese, IT
• Iain Lingard · Monza, IT
• Rocco Mazzaferro · San Giuliano Milanese, IT
• Holger Rosenbrock · Mittelbiberach, DE

Key dates

• Filing date: Jul 27, 2012
• Grant date: Apr 21, 2015
• Expiry date: Sep 21, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Substituted phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones which are glycine transporter-1 (GlyT1) inhibitors. These are useful for the treatment of schizophrenia, Alzheimer's Disease and other neurological and psychiatric disorders.