Probe for detecting ABL gene mutation and uses thereof
US9012619B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | Feb 19, 2008 |
| Grant date | Apr 21, 2015 |
| Priority date | — |
| Expiry date | Jan 2, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/172
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Detection probes are provided that are capable of detecting a sequence to be detected containing a mutation even when a sequence not to be detected containing no mutation coexists with the sequence to be detected containing a mutation, which are different only in a single base from each other. At least one oligonucleotide selected from the group consisting of SEQ ID NOs: 2˜16 is used as a probe. Even in a sample containing an abl gene in which a mutation has occurred and an abl gene in which no mutation has occurred, the use of such probes in, for example, Tm analysis allows the mutation to be detected.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.