1,3-oxazolidine-2-one-like compound, preparation method and uses thereof

US9012631B2 · kind B2 · utility

Assignees

• Yabang Pharmaceutical Co., Ltd · CN
• Jiangsu Yabang Shengyuan Pharmaceutical Co., Ltd · CN
• Changzhou Yabang Pharmaceutical Co., Ltd · CN

Inventors

• Si Wang · San Diego, US
• Yong Deng · Sichuan, CN
• Zai-Xin Chen · 安丰镇, CN
• Hui Zhang · Jinan, CN
• Zhi-Pei San · Sichuan, CN
• Bai-Yang Mao · 安丰镇, CN
• Zheng-Jun Xia · 安丰镇, CN
• Long Jiang · Santa Clara, US
• Ming Zhang · Beijing, CN
• Song Lin · Rouses Point, US
• Ming WANG · Batou, CN

Key dates

• Filing date: Aug 10, 2011
• Grant date: Apr 21, 2015
• Expiry date: Aug 24, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D263/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention provides 1,3-oxazolidin-2-one compounds of formula I and their salts, their preparation methods, and use in the preparation of linezolid racemate and its optical isomer, which are used as oxazolidinone antibacterial agents. In the formula, R is H, hydroxyl, halogen, C1-C12 alkyl, C1-C12 alkoxy, nitro and carboxyl; and R can be placed at any position on the benzene rings; and the compound is a racemate or an optical isomer.