Methods for the prognosis of breast cancer

US9017944B2 · kind B2 · utility

Assignee

• EPIGENOMICS AG · DE

Inventors

• John Foekens · Capelle aan den IJssel, NL
• Nadia Harbeck · Otterfing, DE
• Thomas Koenig · Berlin, DE
• Sabine Maier · Brussels, BE
• John W. Martens · Rotterdam, NL
• Fabian Model · Berlin, DE
• Inko Nimmrich · Berlin, DE
• Manfred Schmitt · Munich, DE
• Ralf Lesche · Berlin, DE
• Dimo Dietrich · Berlin, DE
• Volkmar Mueller · Hamburg, DE
• Antje Kluth Lukas · Bargteheide, DE
• Ina Schwope · Berlin, DE
• Oliver Hartmann · Raleigh, US
• Peter Adorjan · Berlin, DE
• Almuth Marx · Nuremberg, DE
• Heinz Hoefler · Munich, DE

Key dates

• Filing date: Dec 13, 2004
• Grant date: Apr 28, 2015
• Expiry date: Apr 7, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/16
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the disease free survival and/or response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.