3,4,4a,10b-Tetrahydro-1H-thiopyrano-[44,3-c] isoquinoline derivatives

US9018175B2 · kind B2 · utility

Assignee

• TAKEDA GMBH · DE

Inventors

• Dieter Flockerzi · Allensbach, DE
• Thomas Stengel · Konstanz, DE
• Alexander Mann · Radolfzell, DE
• Harald Ohmer · Singen, DE
• Ulrich Kautz · Allensbach, DE
• Steffen Weinbrenner · Konstanz, DE
• Stefan Fischer · Freinsheim, DE
• Christof Zitt · Konstanz, DE
• Armin Hatzelmann · Konstanz, DE
• Torsten Dunkern · Refrath, DE
• Christian Hesslinger · Zoznegg, DE
• Thomas Maier · Stockach, DE
• Hermann Tenor · Konstanz, DE
• Clemens Braun · Konstanz, DE
• Raimund Külzer · Konstanz, DE
• Degenhard Marx · Radebeul, DE

Key dates

• Filing date: Dec 15, 2010
• Grant date: Apr 28, 2015
• Expiry date: Dec 23, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The compounds of Formula (1),in which A, R1, R2, R3 and R5 have the meanings as given in the description, are novel effective inhibitors of type 4 and 5 phosphodiesterase.