Pharmaceutical composition and dosage form comprising dronedarone, and preparation method thereof
US9018250B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 6, 2013 |
| Grant date | Apr 28, 2015 |
| Priority date | — |
| Expiry date | May 6, 2033 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The disclosure relates to a pharmaceutical composition for oral administration, containing, as active principle, a benzofuran derivative having antiarrhythmic activity, in particular dronedarone and the pharmaceutically acceptable salts thereof, and at least one lipid carrier, said pharmaceutical composition being intended to be used in unit dosage form of the capsule type, in particular with a hard shell. This pharmaceutical composition and the dosage form comprising such a composition aim to limit the meal time effect following oral administration in humans. The lipid carrier allows: the solubilization of the active principle of the invention; and the shielding thereof from the negative effects of pH in the intestinal tract, thereby allowing same to be spared from the meal effect to a significant extent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.