Adenosine derivatives, method for the synthesis thereof, and the pharmaceutical compositions for the prevention and treatment of the inflammatory diseases containing the same as an active ingredient

US9018371B2 · kind B2 · utility

Assignees

• FM Therapeutics Co., Ltd. · KR
• THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, OFFICE OF TECHNOLOGY TRANSFER—NATIONAL INSTITUTES OF HEALTH · US

Inventors

• Lak Shin Jeong · Seoul, KR
• Hea Ok Kim · Seoul, KR
• Kenneth A. Jacobson · Silver Spring, US
• Seung Ah Choe · Seoul, KR

Key dates

• Filing date: Mar 7, 2007
• Grant date: Apr 28, 2015
• Expiry date: May 5, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are adenosine derivatives, methods for the synthesis thereof, and pharmaceutical compositions for the prevention and treatment of inflammatory diseases, comprising the same as an active ingredient. The adenosine derivatives have high binding affinity and selectivity for adenosine receptors, especially for A3 adenosine receptors and act as A3 adenosine receptor antagonists, and exhibit anti-inflammatory activity. Thus, the adenosine derivatives are useful in the prevention and treatment of inflammatory diseases.