Patent · US Active

Acylamino-substituted cyclic carboxylic acid derivatives and their use as pharmaceuticals

US9018383B2 · kind B2 · utility

0Cited by

10References

9Claims

0Family size

Assignee

Sanofi · FR

Inventors

Josef Pernerstorfer · Wuppertal, DE
Heinz-Werner Kleemann · Bischofsheim, DE
Matthias Schaefer · Frankfurt am Main, DE
Alena Safarova · Bound Brook, US
Marcel Patek · Tucson, US

Key dates

Filing date	Nov 27, 2013
Grant date	Apr 28, 2015
Priority date	—
Expiry date	Nov 27, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C2602/50
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to compounds of the formula I,wherein A, Y, Z, R20 to R22 and R50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2 (Edg-2, EDG2), which is activated by lysophosphatidic acid (LPA) and is also termed as LPA1 receptor, and are useful for the treatment of diseases such as atherosclerosis, myocardial infarction and heart failure, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.