Anti-mesothelin antibodies and uses thereof

US9023351B2 · kind B2 · utility

Assignee

• Bayer Intellectual Property GmbH · DE

Inventors

• Antje Kahnert · Wuppertal, DE
• David Light · San Mateo, US
• Doug SCHNEIDER · Lafayette, US
• Renate Parry · Oakland, US
• Noboru Satozawa · Chiba, JP
• Tara Renee Heitner Hansen · Middelfart, DK
• Stefan Steidl · Munich, DE
• Ulrike Schubert · Birkenfeld, DE

Key dates

• Filing date: Nov 19, 2008
• Grant date: May 5, 2015
• Expiry date: May 26, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 4O.kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of mesothelin in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.