Patent · US Active

Compositions and methods for treating renal disease

US9023355B2 · kind B2 · utility

3Cited by

1References

9Claims

0Family size

Assignee

Beth Israel Deaconess Medical Center, Inc. · US

Inventors

David J. Friedman · San Antonio, US
Martin R. Pollak · Brookline, US

Key dates

Filing date	Feb 24, 2012
Grant date	May 5, 2015
Priority date	—
Expiry date	Jul 10, 2032

Classification

Technology area (CPC G)Physics
CPC primaryG01N2800/50
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Compositions and methods are disclosed herein for treating or reducing the symptoms of a renal disease, such as focal segmental glomerulosclerosis (FSGS), hypertensive end-stage kidney disease (ESKD), and HIV-associated nephropathy (a distinct form of FSGS, also termed collapsing glomerulopathy). The compositions include the common variant of APOL1 and fragments thereof, as well as antibodies and fragments thereof that bind and neutralize pathogenic APOL1, nucleic acid molecules that encode the common variant of APOL1 and fragments thereof, and other compounds that bind and neutralize pathogenic APOL1. The methods of the invention include administering one or more of the compositions of the invention to a subject having or at risk of developing renal disease.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.