Microbial succinic acid producers and purification of succinic acid

US9023632B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Hartwig Schröder · Nümbrecht, DE
• Stefan Haefner · Speyer, DE
• Gregory Von Abendroth · Mannheim, DE
• Rajan Hollmann · Worms, DE
• Aline Raddatz · Mannheim, DE
• Hansgeorg Ernst · Speyer, DE
• Hans Gurski · Lambsheim, DE

Key dates

• Filing date: Jan 8, 2014
• Grant date: May 5, 2015
• Expiry date: Jan 8, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12R2001/01
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.