Reactive mass labels

US9023656B2 · kind B2 · utility

Assignee

• ELECTROPHORETICS LIMITED · GB

Inventors

• Christian Hamon · Saint-Nazaire, FR
• Josef Schwarz · Augsburg, DE
• Wolfgang Becker · Eppstein, DE
• Stefan Kienle · Frankfurt, DE
• Karsten Kuhn · Dortmund, DE
• Juergen Schaefer · Lauterbach, DE

Key dates

• Filing date: Jul 26, 2006
• Grant date: May 5, 2015
• Expiry date: Feb 28, 2029

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/24
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A mass label for labelling and detecting a biological molecule by mass spectroscopy, which label comprises the following structure: X-L-M wherein X is a mass marker moiety comprising the following group: formula (I), wherein the cyclic unit is aromatic or aliphatic and comprises from 0-3 double bonds independently between any two adjacent atoms; each Z is independently N, N(R1), C(R1), CO, CO(R1), C(R1)2, O or S; X is N, C or C(R1); each R1 is independently H, a substituted or unsubstituted straight or branched C1-C6 alkyl group, a substituted or unsubstituted aliphatic cyclic group, a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group; and y is an integer from 0-10, L is a cleavable linker comprising an amide bond and M is a mass normalization moiety.