Antidotes for factor XA inhibitors and methods of using the same

US9023796B2 · kind B2 · utility

Assignee

• Portola Pharmaceuticals, Inc. · US

Inventors

• Genmin Lu · South San Francisco, US
• David R. Phillips · Hillsborough, US
• Patrick Andre · San Mateo, US
• Uma Sinha · San Francisco, US

Key dates

• Filing date: May 7, 2013
• Grant date: May 5, 2015
• Expiry date: May 7, 2033

Classification

• Technology area (CPC —): General

Abstract

The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.