Macrocyclic inhibitors of hepatitis C virus

US9023808B2 · kind B2 · utility

Assignees

• MEDIVIR AB · SE
• Janssen R & D Ireland · IE

Inventors

• Kenneth Alan Simmen · Tervuren, BE
• Herman Agustinus De Kock · Arendonk, BE
• Carl Erik Daniel Jonsson · Huddinge, SE
• Karl Magnus Milsson · Vimmerby, SE
• Bengt Bertil Samuelsson · Skärholmen, SE
• Asa Annica Kristina Rosenquist · Huddinge, SE
• Susana Ayesa Alverez · Sollentuna, SE
• Bjorn Olaf Classon · Stockholm, SE
• Hans Wallberg · Stuvsta-Snättringe, SE

Key dates

• Filing date: Jan 16, 2008
• Grant date: May 5, 2015
• Expiry date: Dec 19, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Inhibitors of HCV replication of formula (I)and the N-oxides, salts, or stereoisomers thereof, wherein the dashed line, X, R1, R2, R3, R4, R5, R6, and R7 have defined meanings; the preparation thereof; compositions containing compounds of formula (I), including bioavailable combinations with ritonavir; and the pharmaceutical uses thereof.