Patent · US Active

Hydrophobic interaction chromatography purification of factor VII polypeptides

US9023992B2 · kind B2 · utility

14Cited by

38References

12Claims

0Family size

Assignee

Novo Nordisk Health Care AG · CH

Inventors

Daniel E. Rasmussen · Middelfart, DK
Janus Krarup · Copenhagen, DK

Key dates

Filing date	Sep 17, 2010
Grant date	May 5, 2015
Priority date	—
Expiry date	Dec 22, 2033

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P7/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention described herein provides new methods of preparing purified Factor VII polypeptide drug substances in large quantities (industrial scale levels) that are associated with reduced content of product-related impurities (e.g., late eluting peaks) and/or that exhibit a relatively uniform glycosylation pattern.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.