Method for purifying rocuronium bromide

US9024013B2 · kind B2 · utility

Assignee

• ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. · CN

Inventors

• Zhiwen Zeng · Zhejiang, CN
• Peng Wang · San Diego, US
• Wenling Zhang · 马宅镇, CN
• Xini Zhang · Shanghai, CN

Key dates

• Filing date: Apr 25, 2011
• Grant date: May 5, 2015
• Expiry date: Apr 25, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J43/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided is a method for purifying rocuronium bromide, which comprises: formulating crude rocuronium bromide to be purified into an aqueous solution, distilling off excess residue solvents at reduced pressure, absorbing by adding active carbon or silica gel, then filtrating, quick freezing the filtrate into ice, and then lyophilizing to obtain rocuronium bromide.