Process for the synthesis of etoricoxib

US9024030B2 · kind B2 · utility

Assignees

• ALFRED E. TIEFENBACHER (GMBH & CO. KG) · DE
• SHANGHAI GOLDEN PHARMATECH CO., LTD. · CN

Inventors

• Zhenmin Mao · Shanghai, CN
• Tian Lan · Milpitas, US
• Lanfang Liu · Shanghai, CN
• Long Yan · Beijing, CN
• Stefan Becker · Mannheim, DE

Key dates

• Filing date: Jan 11, 2013
• Grant date: May 5, 2015
• Expiry date: Jan 11, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/61
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for the synthesis of the anti-inflammatory agent 5-chloro-3-(4-methanesulfonylphenyl)-6′-methyl-[2,3′]bipyridine, referred to as compound of formula (1) or etoricoxib, which is a pharmaceutically active ingredient inhibiting cyclooxygenase-2. In particular, the application concerns a novel process of making the compound of formula (1) by oxidizing a compound of formula (4).