Materials and methods useful to induce cell death via methuosis

US9028796B2 · kind B2 · utility

Assignee

• The University of Toledo · US

Inventors

• William A. Maltese · Toledo, US
• Paul W. Erhardt · Toledo, US
• Michael Robinson · Beaverton, US
• Jean H. Overmeyer · Perrysburg, US

Key dates

• Filing date: Feb 24, 2012
• Grant date: May 12, 2015
• Expiry date: Mar 18, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B40/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.