Cross-linked peptides and proteins, methods of making same, and uses thereof

US9029332B2 · kind B2 · utility

Assignee

• The Research Foundation for The State University of New York · US

Inventors

• Qing Lin · San Diego, US
• Avinash Muppidi · Carmel, US

Key dates

• Filing date: Dec 15, 2011
• Grant date: May 12, 2015
• Expiry date: Mar 23, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/95
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Cross-linked proteins and peptides, and methods of making and uses of such cross-linked proteins and peptides. The cross-linked proteins and peptides have rigid, distance-matching bismethylene aryl cross-linking moieties. Compositions comprising the cross-linked proteins and peptides can be used as pharmaceutical delivery formulations. The cross-linked proteins and peptides can have improved properties, such as cell permeability, as compared to the parent protein or peptide.