Process for the preparation of C-FMS kinase inhibitors

US9029352B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Krzysztof KOLODZIEJCZYK · Reading, GB
• Alfred Elisabeth Stappers · Oud-Turnhout, BE
• Christopher A. Teleha · Fort Washington, US
• Koen Johan Herman Weerts · Vosselaar, BE

Key dates

• Filing date: Aug 5, 2013
• Grant date: May 12, 2015
• Expiry date: Aug 5, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to a process for the preparation of heterocyclic derivatives of formula Iwherein J, X, Z, and R2 are as defined herein. Such compounds are useful as protein tyrosine kinase inhibitors, more particularly inhibitors of c-fms kinase.