N-carboxyalkylauristatins and use thereof

US9029406B2 · kind B2 · utility

Assignee

• SEATTLE GENETICS, INC. · US

Inventors

• Hans-Georg Lerchen · Leverkusen, DE
• Sherif El Sheikh · Essen, DE
• Beatrix Stelte-Ludwig · Wülfrath, DE
• Joachim Schuhmacher · Wuppertal, DE
• Mark Jean Gnoth · Mettmann, DE

Key dates

• Filing date: Mar 12, 2012
• Grant date: May 12, 2015
• Expiry date: Mar 12, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/6415
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application relates to new derivatives, substituted on the N terminus by a carboxyalkyl group, of monomethylauristatin E and monomethylauristatin F, to processes for preparing these derivatives, to the use of these derivatives for treating and/or preventing diseases, and to the use of these derivatives for producing medicaments for treating and/or preventing diseases, more particularly hyperproliferative and/or angiogenic disorders such as cancer disorders, for example. Such treatments may be applied as a monotherapy or else in combination with other medicaments or further therapeutic measures.