Method for native ligation of polypeptides
US9029503B2 · kind B2 · utility
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22Claims
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Key dates
| Filing date | Oct 28, 2010 |
| Grant date | May 12, 2015 |
| Priority date | — |
| Expiry date | Jun 16, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/026
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention mainly relates to a method for manufacturing a polypeptide of formula:X1—X″—X2 (III)X1 and X2 each representing a peptide fragment, and X″ representing an amino acid residue comprising a thiol function, said method comprising at least one step of ligation reaction between a polypeptide of formula:X1—N(CH2CH2SH)2 (I)and a polypeptide of formula:H—X″—X2. (II)The invention also relates to the polypeptides of formula (I) themselves and the method for obtaining them, as well as resin supports suitable for obtaining them.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.