Chromatography media and method

US9029517B2 · kind B2 · utility

Assignee

• EMD Millipore Corporation · US

Inventors

• David Yavorsky · Bolton, US
• John P. Amara · Reading, US
• Joaquin Umana · Stoneham, US
• William Cataldo · Burlington, US
• Mikhail Kozlov · Lexington, US
• Matthew T. Stone · Cambridge, US

Key dates

• Filing date: Jul 27, 2011
• Grant date: May 12, 2015
• Expiry date: Dec 25, 2031

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2973
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).