Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation

US9029544B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Holger Wagner · Mettenberg, DE
• Daniela Berta · Milano, IT
• Klaus Fuchs · Ingelheim am Rhein, DE
• Riccardo Giovannini · Verona, IT
• Dieter Hamprecht · Verona, IT
• Ingo Konetzki · Warthausen, DE
• Ruediger Streicher · Biberach, DE
• Thomas Trieselmann · Ochsenhausen, DE

Key dates

• Filing date: Feb 17, 2011
• Grant date: May 12, 2015
• Expiry date: May 30, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds defined by formula Iwherein the variables R1-R8 are defined as in the description, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of cholesterol ester transfer protein (CETP) and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme.