Low molecular weight cationic lipids for oligonucleotide delivery
US9029590B2 · kind B2 · utility
40Cited by
3References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 17, 2011 |
| Grant date | May 12, 2015 |
| Priority date | — |
| Expiry date | Oct 17, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids comprising at least one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.