Protected aldehydes for use as intermediates in chemical syntheses, and processes for their preparation
US9029607B2 · kind B2 · utility
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12References
5Claims
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Key dates
| Filing date | Jul 22, 2011 |
| Grant date | May 12, 2015 |
| Priority date | — |
| Expiry date | Jul 22, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C47/575
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A para-methoxy protected benzaldehyde useful in preparation of treprostinil, and of formula: (Formula (1)) is prepared by subjecting to Claisen re-arrangement a substituted benzaldehyde of formula (1a): (Formula (Ia)) to form the m-hydroxy-substituted benzaldehyde of formula (1b): (Formula (Ib)) and then reacting compound (1b) with a p-methoxybenzyl (PMB) compound to form a PMB-substituted benzaldehyde of formula (1).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.