Genes encoding major capsid protein L1 of human papilloma virus

US9034340B2 · kind B2 · utility

Assignee

• Shanghai Zerun Biotechnology Co., Ltd. · CN

Inventors

• Goaxia Zhang · Shanghai, CN
• Qiong Shen · Shanghai, CN
• Jianqiang Lei · Shanghai, CN
• Jingyu Yuan · Shanghai, CN
• Menghua Zhang · Shanghai, CN
• Qianli Zhang · Longbeilingcun, CN
• Yinghua Xiong · Shanghai, CN
• Roger Wei · Shanghai, CN
• Ke Wu · Shanghai, CN

Key dates

• Filing date: Jun 5, 2014
• Grant date: May 19, 2015
• Expiry date: Jun 5, 2034

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2982
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention discloses a codon-optimized gene encoding major capsid protein L1 of human papilloma virus, which is capable, after transduced into a yeast cell, of efficiently expressing the major capsid protein L1 of human papilloma virus. The present invention also discloses an immunogenic macromolecule which is essentially produced by expression of said codon-optimized gene encoding the major capsid protein L1 of human papilloma virus in a yeast cell. The present invention further discloses the use of said immunogenic macromolecule and a composition comprising said immunogenic macromolecule.