Lipid construct for delivery of insulin to a mammal
US9034372B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 10, 2014 |
| Grant date | May 19, 2015 |
| Priority date | — |
| Expiry date | Oct 10, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P3/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The instant invention is drawn to a hepatocyte targeted composition comprising insulin associated with a lipid construct comprising an amphipathic lipid and an extended amphipathic lipid that targets the construct to a receptor displayed by an hepatocyte. The composition can comprise a mixture of free insulin and insulin associated with the complex. The composition can be modified to protect insulin and the complex from degradation. The invention also includes methods for the manufacture of the composition and loading insulin into the composition and recycling various components of the composition. Methods of treating individuals inflicted with diabetes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.