Oseltamivir phosphate granule and preparation method thereof

US9034382B2 · kind B2 · utility

Assignee

• INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY, ACADEMY OF MILITARY MEDICAL SCIENCES · CN

Inventors

• Song Li · Beijing, CN
• Wu Zhong · Beijing, CN
• Junhai Xiao · Beijing, CN
• Yunde Xie · Beijing, CN
• Xingzhou Li · Beijing, CN
• Hao Cui · Beijing, CN
• Zhibing Zheng · Beijing, CN

Key dates

• Filing date: Aug 11, 2006
• Grant date: May 19, 2015
• Expiry date: Jul 20, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/0056
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to an oseltamivir phosphate granule and preparation method thereof. The said granule comprises 1.97-19.8 wt. % oseltamivir phosphate, 75.0-97.5 wt. % diluent, 0.1-5.0 wt. % binder, optionally 1.0-5.0 wt. % edible flavoring essence, sweetener and/or edible pigment. It is prepared by using 30-55 v/v % aqueous ethanol solution as moistening agent. The granules prepared by the formulation and method according to the present invention have good uniformity and stability and are water-soluble. The administration dosage of the granules can be conveniently selected based on the age and body weight of patients. The oseltamivir phosphate granule is suitable for administering to old people, children and flu gravis patients and those patients that swallow inconveniently or difficulty. The preparation of the granule is simple and low in production cost.