Three-dimensional, prevascularized, engineered tissue constructs, methods of making and methods of using the tissue constructs

US9034571B2 · kind B2 · utility

Assignees

• THE UAB RESEARCH FOUNDATION · US
• Southern Research Institute · US

Inventors

• Joel L. Berry · Winston-Salem, US
• Timothy M. Wick · Homewood, US
• Joanne Murphy-Ullrich · Birmingham, US
• Andrew Penman · Birmingham, US
• Andrew W. Cain · Birmingham, US
• Andra Rixse Frost · Birmingham, US

Key dates

• Filing date: Mar 6, 2013
• Grant date: May 19, 2015
• Expiry date: Mar 6, 2033

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/10
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Three-dimensional (3D), prevascularized, engineered tissue constructs, 3D prevascularized engineered tissue models of cancer, and bioreactors and bioreactor arrays including the tissue constructs are disclosed. Methods of making the tissue constructs, methods of using the tissue constructs, methods of drug discovery using the tissue constructs and/or cancer models, and the like are also disclosed.