sgp130/Fc dimers for treatment of inflammatory disease

US9034817B2 · kind B2 · utility

Assignee

• CONARIS Research Institute AG · DE

Inventors

• Georg H. Wätzig · Kiel, DE
• Dirk Seegert · Dänischenhagen, DE

Key dates

• Filing date: Dec 17, 2013
• Grant date: May 19, 2015
• Expiry date: Dec 17, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described are polypeptide dimers comprising two soluble gp130 molecules wherein each of said molecules is fused to an Fc domain of an IgG1 protein and wherein the hinge region of the Fc domain is modified resulting in advantageous properties of the dimer. In a particularly preferred embodiment, the hinge region comprises the amino acid sequence motif Ala234-Glu235-Gly236-Ala237. Moreover, a pharmaceutical composition containing said dimer and various medical uses are described.