17-(1′propenyl)-17-3′-oxidoestra-4-en-3-one derivative, use thereof, and medicament containing said derivative

US9034856B2 · kind B2 · utility

Assignee

• Bayer Intellectual Property GmbH · DE

Inventors

• Ulrich Klar · Berlin, DE
• Joachim Kuhnke · Leverkusen, DE
• Rolf Bohlmann · Berlin, DE
• Jan Hübner · Berlin, DE
• Sven Ring · Jena, DE
• Thomas Frenzel · Berlin, DE
• Frederik Menges · Schriesheim, DE
• Steffen Borden · Berlin, DE
• Hans-Peter Muhn · Berlin, DE
• Katja Prelle · Berlin, DE

Key dates

• Filing date: Dec 23, 2008
• Grant date: May 19, 2015
• Expiry date: Jan 8, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J53/007
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to 17-(1′-propenyl)-17-3′-oxidoestra-4-en-3-one derivatives with the general chemical formula I, where the residues Z, R4, R6a, R6b, R7, R15, R16a, R16b and R18 have the meanings stated in Claim 1, and their solvates, hydrates and salts, including all stereoisomers of these compounds. The invention further relates to the use of these derivatives for the production of a medicinal product for oral contraception and for the treatment of pre-, peri- and postmenopausal complaints and medicinal products that contain said derivatives, and in particular application in the aforementioned indications. The derivatives according to the invention have a progestational and in preferred cases additionally an antimineralocorticoid and neutral to slightly androgenic action.