Azaindenoisoquinoline topoisomerase I inhibitors

US9034870B2 · kind B2 · utility

Assignees

• Purdue Research Foundation · US
• United States Government National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), NIH Division of Extramural Inventions and Technology Resources (DEITR) · US

Inventors

• Mark S. Cushman · West Lafayette, US
• Evgeny A. Kiselev · West Lafayette, US
• Andrew E. Morrell · San Diego, US
• Yves G. Pommier · Bethesda, US

Key dates

• Filing date: Mar 6, 2014
• Grant date: May 19, 2015
• Expiry date: Mar 6, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention described herein pertains to substituted azaindenoisoquinoline compounds, in particular 7-, 8-, 9-, and 10-azaindenoisoquinoline compounds, which are inhibitors of topoisomerase I, processes and intermediates for their syntheses, pharmaceutical compositions of the compounds, and methods of using them in the treatment of cancer.